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KMID : 0869620140310030817
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Journal of Korean Society of Hospital Pharmacists
2014 Volume.31 No. 3 p.817 ~ p.825
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Effectiveness and Incidence of Hypoglycemia in the Combination of Sitagliptin and Sulfonylurea, in Patients with Type 2 Diabetes Mellitus
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Kang Min-Kyong
Jung Sun-Hoi
Kim Hyang-Suk
Oh Jung-Mi
Choi Kyung-Hee
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Abstract
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Background : Sitagliptin, which inhibits dipeptidyl polypeptidase-4 and stimulate the secretion of insulin, is primarily used as a combination therapy with other oral hypoglycemic drugs. Sitagliptin is known to have lower incidence in hypoglycemia compared to other oral hypoglycemic drugs. However, several studies suggest that combination therapy including sitagliptin, can cause hypoglycemia. The aim of this study is to analyze the effectiveness and the frequency of hypoglycemia in Korean patients with type 2 diabetes treated with sitagliptin and sulfonylurea.
Methods : From August 2008 to April 2010, we retrospectively reviewed the electronic medical records of type 2 diabetes patients who were prescribed sulfonylurea and sitagliptin over a period of 6 months at Seoul National University Hospital. We excluded patients who had been using insulin as well as those, who had ESRD or kidney transplantation.
Results : A total of 232 Korean patients were enrolled in this study. The effectiveness in the reduction of blood glucose was statistically significant (P<0.05). In the sulfonylurea maintenance group (n=206), 10 patients experienced hypoglycemia, however two of them were not related to the medicine. In the sulfonylurea reduction group (n=26), one patient who had problems of alcohol abuse, experienced hypoglycemia. Therefore, he recovered from hypoglycemia after quitting drinking.
Conclusions : In this study, the combination therapy of sitagliptin and sulfonylurea significantly improved glycemic control. Yet, hypoglycemia occurred in some patients after adding sitagliptin.
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KEYWORD
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Type 2 DM, Sulfonylurea, Sitagliptin, Hypoglycemia
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